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KMID : 0616619970030020573
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Journal of Soonchunhyang Medical College
1997 Volume.3 No. 2 p.573 ~ p.580
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WTI gene expression as a useful marker for the detection of minimal residual disease in acute ieukemia
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Abstract
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The Wilms´ tumor gene(WTI) has been shown to be expressed in the vast majority of patients with acute leukemia and evaluated as a possible marker for detection of minimal residual disease. Ve examined the WTI mRNA expression in bone marrow or peripheral blood of 14 patients with aukemias(8 acute lymphocytic leukemia [ALL] , 3 acute myeloid leukemia [AMLI , 1 chronic nyeloid leukemia [CML) , 1 chronic lymphocytic leukemia [CLL1 and 1 hairy cell leukemia) and 0 normal adults. RNA was isolated from each sample and reverse transcription-polymerase chain eaction was performed to test WTI expression. WTI was expressed in leukemc cells from (63%) of 8 ALL and 2(67%) of 3 AML patients at diagnosis. WTI was not detected in other ukemic patients and all 10 normal adults. The WTI became undetectable in a patient with ALL fter complete remission. Complete remission was not achieved in a patient that WTI gene xpression didn´t decrease. In conclusion, WTI may be a new marker for the diagnosis of acute mkemia and further studies are necessary to elucidate whether the WTI would be useful in --onitoring therapy, early detection of leukemic relapse and predicting prognosis.
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KEYWORD
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